[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 9, Issue 3 (2-2013) ::
Mod Care J 2013, 9(3): 173-180 Back to browse issues page
Effect of long term consumption of Sodium Benzoat before and during pregnancy on growth indexes of Fetal Balb/c mice
M. Afshar , S.A Moallem , M. Hasanzadeh Taheri , M. Shahsavan , F. Sukhtanloo , F. Salehi
Mashhad Branch, Islamic Azad University, Mashhad, Iran , marjan.shahsavan@yahoo.com
Abstract:   (7448 Views)

  Background and Aim: Food additives, such as sodium benzoate (SB), are used in many food products and drugs to postpone the growth of microrganisms. The aim of the present study was to evaluate the effects of long term consumption of SB on the growth indexes of Balb/c mice.

  Materials and Methods: In this experimental study, 30 female Balb/c mice were divided into 2 experimental (I, II) and one control groups. The experimental groups (I, II) daily received 280 and 560 mg/kg of SB intrapretoneally, respectively. The control group received normal saline in the same way. All injections were done during 10 days before gestation, and then, between the 6th and the 15th of gestational days (GD6-15). The mice underwent cesarean section on GD 18 and their embryos were removed. Then, weighing the embryos and measuring their length were done. The embryos were stained with alizarin red and alcian blue and observed by means of a stereomicroscope. The obtained data was analyzed using SPSS software and statistical tests one-way variance analysis, Tukey, and c 2 at the significant level P<0.05.

  Result: Mean weight and crown-rump of the fetuses in the experimental group II significantly decreased in comparison with the experimental group I and the control group. The fetal resorption in the experimental groups I and II significantly decreased in comparison with the control group (P=0.04).

  Conclusion: SB consumption before and during pregnancy can probably induce negative changes of fetal indexes . Thus, it is recommended that pregnant women cautiously use food stuffs containing sodium benzoate, as far as possible.

Keywords: Sodium benzoate, Growth and Development, Food Additives, Mice, Inbred BALB C.
Full-Text [PDF 607 kb]   (1575 Downloads)    
Type of Study: Experimental | Subject: Phamacology
Received: 2012/10/16 | Accepted: 2013/01/20
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Afshar M, Moallem S, Hasanzadeh Taheri M, Shahsavan M, Sukhtanloo F, Salehi F. Effect of long term consumption of Sodium Benzoat before and during pregnancy on growth indexes of Fetal Balb/c mice. Mod Care J. 2013; 9 (3) :173-180
URL: http://moderncare.bums.ac.ir/article-1-120-en.html

Volume 9, Issue 3 (2-2013) Back to browse issues page
مراقبتهای نوین Modern Care Journal
Persian site map - English site map - Created in 0.24 seconds with 31 queries by YEKTAWEB 3781